Obvious in Hindsight II

Don't be afraid to do the maximum possible damage to PC's in the first round or two of combat, especially if you've got the drop on them and you're attacking them while they're flat-footed. It may be tempting to throttle back a little as you bring DPS'ers and casters down to single-digit hit-points, but believe me, as soon as they get their Dexterity back and start buffing eachother, you'll be back to needing 20's to hit them before you can say Haste.

Obvious in Hindsight I

If a monster has a reach of over 5 feet, move into point-blank range anyway. Assuming it can attack anywhere within its reach, even PC's who use a Withdraw action won't be able to escape an Attack of Opportunity.